[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse CCDC155

Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus outer membrane Single-pass type IV membrane protein Cytoplasmic side Nucleus Chromosome, telomere Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Domain PF14662 Coiled-coil region of CCDC155 or KASH
Function

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007015 actin filament organization
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007129 synapsis
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0034397 telomere localization
GO:0045132 meiotic chromosome segregation
GO:0045143 homologous chromosome segregation
GO:0048232 male gamete generation
GO:0048477 oogenesis
GO:0050000 chromosome localization
GO:0051225 spindle assembly
GO:0051303 establishment of chromosome localization
GO:0051321 meiotic cell cycle
GO:0051640 organelle localization
GO:0051653 spindle localization
GO:0051656 establishment of organelle localization
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation
GO:0098813 nuclear chromosome segregation
GO:1903046 meiotic cell cycle process
Molecular Function GO:0070840 dynein complex binding
Cellular Component GO:0000781 chromosome, telomeric region
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0000800 lateral element
GO:0000922 spindle pole
GO:0005635 nuclear envelope
GO:0005640 nuclear outer membrane
GO:0005819 spindle
GO:0019867 outer membrane
GO:0031965 nuclear membrane
GO:0031968 organelle outer membrane
GO:0034992 microtubule organizing center attachment site
GO:0034993 LINC complex
GO:0044454 nuclear chromosome part
GO:0072687 meiotic spindle
GO:0090619 meiotic spindle pole
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CCDC155 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CCDC155 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.56; FDR: 0.02000 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CCDC155 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.170.402
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0510.918
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3310.383
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0090.986
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0050.996
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0260.985
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3350.605
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0170.99
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7380.614
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2710.288
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CCDC155 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CCDC155. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CCDC155. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CCDC155.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CCDC155. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CCDC155 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CCDC155 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCCDC155
Namecoiled-coil domain containing 155
Aliases FLJ32658; KASH5; KASH domain-containing protein 5; Coiled-coil domain-containing protein 155; Protein KASH5
Chromosomal Location19q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CCDC155 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.