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Browse ATP6V1H

Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF11698 V-ATPase subunit H
Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.

> Gene Ontology
 
Biological Process GO:0000041 transition metal ion transport
GO:0002697 regulation of immune effector process
GO:0002831 regulation of response to biotic stimulus
GO:0006818 hydrogen transport
GO:0006826 iron ion transport
GO:0006885 regulation of pH
GO:0006914 autophagy
GO:0007035 vacuolar acidification
GO:0008286 insulin receptor signaling pathway
GO:0009615 response to virus
GO:0010506 regulation of autophagy
GO:0015672 monovalent inorganic cation transport
GO:0015682 ferric iron transport
GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030641 regulation of cellular pH
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033572 transferrin transport
GO:0043434 response to peptide hormone
GO:0043900 regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0045851 pH reduction
GO:0050688 regulation of defense response to virus
GO:0050690 regulation of defense response to virus by virus
GO:0050792 regulation of viral process
GO:0051452 intracellular pH reduction
GO:0051453 regulation of intracellular pH
GO:0051607 defense response to virus
GO:0055067 monovalent inorganic cation homeostasis
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0072512 trivalent inorganic cation transport
GO:0090382 phagosome maturation
GO:0090383 phagosome acidification
GO:0090662 ATP hydrolysis coupled transmembrane transport
GO:0098542 defense response to other organism
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902600 hydrogen ion transmembrane transport
Molecular Function GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0019829 cation-transporting ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0036442 hydrogen-exporting ATPase activity
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Cellular Component GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
GO:0005765 lysosomal membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0033176 proton-transporting V-type ATPase complex
GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0098852 lytic vacuole membrane
> KEGG and Reactome Pathway
 
KEGG hsa04142 Lysosome
hsa04145 Phagosome
hsa04150 mTOR signaling pathway
hsa04721 Synaptic vesicle cycle
hsa00190 Oxidative phosphorylation
hsa01100 Metabolic pathways
Reactome R-HSA-1643685: Disease
R-HSA-162906: HIV Infection
R-HSA-162909: Host Interactions of HIV factors
R-HSA-168256: Immune System
R-HSA-5663205: Infectious disease
R-HSA-168249: Innate Immune System
R-HSA-77387: Insulin receptor recycling
R-HSA-983712: Ion channel transport
R-HSA-917937: Iron uptake and transport
R-HSA-167590: Nef Mediated CD4 Down-regulation
R-HSA-182218: Nef Mediated CD8 Down-regulation
R-HSA-164938: Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
R-HSA-1222556: ROS, RNS production in phagocytes
R-HSA-162582: Signal Transduction
R-HSA-74752: Signaling by Insulin receptor
R-HSA-164952: The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-917977: Transferrin endocytosis and recycling
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATP6V1H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATP6V1H in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.71; FDR: 0.00722 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATP6V1H in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2880.205
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3990.861
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2050.904
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1680.52
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0190.991
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3570.862
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.130.753
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2190.9
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0670.973
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1950.897
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5180.82
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0240.696
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ATP6V1H in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATP6V1H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATP6V1H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATP6V1H.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATP6V1H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATP6V1H expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATP6V1H and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATP6V1H
NameATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Aliases CGI-11; VMA13; SFDalpha; SFDbeta; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; MSTP042; V-ATPas ......
Chromosomal Location8q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATP6V1H collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.