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Browse ATG5

Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Domain PF04106 Autophagy protein Apg5
Function

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. ; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. ; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established (PubMed:19666601).

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000422 mitophagy
GO:0006497 protein lipidation
GO:0006501 C-terminal protein lipidation
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0007033 vacuole organization
GO:0009267 cellular response to starvation
GO:0009991 response to extracellular stimulus
GO:0010927 cellular component assembly involved in morphogenesis
GO:0016236 macroautophagy
GO:0018410 C-terminal protein amino acid modification
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0035973 aggrephagy
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042384 cilium assembly
GO:0042594 response to starvation
GO:0043562 cellular response to nitrogen levels
GO:0043687 post-translational protein modification
GO:0044782 cilium organization
GO:0044804 nucleophagy
GO:0060271 cilium morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0061726 mitochondrion disassembly
GO:0071496 cellular response to external stimulus
GO:1902017 regulation of cilium assembly
GO:1902115 regulation of organelle assembly
GO:1903008 organelle disassembly
GO:1905037 autophagosome organization
Molecular Function GO:0019776 Atg8 ligase activity
Cellular Component GO:0000407 pre-autophagosomal structure
GO:0005776 autophagosome
GO:0005929 cilium
GO:0005930 axoneme
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0034274 Atg12-Atg5-Atg16 complex
GO:0044441 ciliary part
GO:0045335 phagocytic vesicle
GO:0097014 ciliary plasm
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-1632852: Macroautophagy
R-HSA-5205647: Mitophagy
R-HSA-936440: Negative regulators of RIG-I/MDA5 signaling
R-HSA-5205685: Pink/Parkin Mediated Mitophagy
R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ATG5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ATG5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.89; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.69; FDR: 0.01650 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ATG5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0730.768
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1680.914
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0120.991
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2760.391
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3720.779
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1570.921
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0230.952
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0290.984
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1030.95
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0230.982
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4330.781
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0140.857
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ATG5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ATG5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ATG5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ATG5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ATG5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ATG5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolATG5
Nameautophagy related 5
Aliases APG5; hAPG5; APG5L; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like (S. cerevisiae); ATG5 auto ......
Chromosomal Location6q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ATG5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.