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Browse ANKRD1

Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF12796 Ankyrin repeats (3 copies)
Function

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.

> Gene Ontology
 
Biological Process GO:0001666 response to hypoxia
GO:0002237 response to molecule of bacterial origin
GO:0003007 heart morphogenesis
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0010720 positive regulation of cell development
GO:0010927 cellular component assembly involved in morphogenesis
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014706 striated muscle tissue development
GO:0030239 myofibril assembly
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0031032 actomyosin structure organization
GO:0031346 positive regulation of cell projection organization
GO:0032496 response to lipopolysaccharide
GO:0034612 response to tumor necrosis factor
GO:0035690 cellular response to drug
GO:0035914 skeletal muscle cell differentiation
GO:0035994 response to muscle stretch
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0042493 response to drug
GO:0042692 muscle cell differentiation
GO:0042770 signal transduction in response to DNA damage
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045214 sarcomere organization
GO:0045666 positive regulation of neuron differentiation
GO:0048644 muscle organ morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050769 positive regulation of neurogenesis
GO:0051047 positive regulation of secretion
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0051146 striated muscle cell differentiation
GO:0051222 positive regulation of protein transport
GO:0051962 positive regulation of nervous system development
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0070482 response to oxygen levels
GO:0070555 response to interleukin-1
GO:0071214 cellular response to abiotic stimulus
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071496 cellular response to external stimulus
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071897 DNA biosynthetic process
GO:0072331 signal transduction by p53 class mediator
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
GO:2000278 regulation of DNA biosynthetic process
GO:2000279 negative regulation of DNA biosynthetic process
GO:2001020 regulation of response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
Molecular Function GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0002039 p53 binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0031432 titin binding
GO:0042826 histone deacetylase binding
GO:0046332 SMAD binding
GO:0070412 R-SMAD binding
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component GO:0005667 transcription factor complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0031674 I band
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1989781: PPARA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ANKRD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ANKRD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ANKRD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1720.678
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5530.433
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1060.86
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4110.532
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2730.259
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6750.603
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0910.901
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5860.599
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5850.671
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4170.672
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.040.975
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7610.0235
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ANKRD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANKRD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANKRD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANKRD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANKRD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ANKRD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ANKRD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolANKRD1
Nameankyrin repeat domain 1 (cardiac muscle)
Aliases C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ......
Chromosomal Location10q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ANKRD1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.