TISIDB

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass type II membrane protein
Domain	PF01179 Copper amine oxidase PF02727 Copper amine oxidase PF02728 Copper amine oxidase
Function	Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.

> Gene Ontology [ TOP ]
Biological Process	GO:0006805 xenobiotic metabolic process GO:0009308 amine metabolic process GO:0009410 response to xenobiotic stimulus GO:0046677 response to antibiotic GO:0071466 cellular response to xenobiotic stimulus
Molecular Function	GO:0005507 copper ion binding GO:0008131 primary amine oxidase activity GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0046982 protein heterodimerization activity GO:0048037 cofactor binding GO:0048038 quinone binding GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity GO:0052594 aminoacetone:oxygen oxidoreductase(deaminating) activity GO:0052595 aliphatic-amine oxidase activity GO:0052596 phenethylamine:oxygen oxidoreductase (deaminating) activity
Cellular Component	GO:0005769 early endosome GO:0005902 microvillus GO:0098858 actin-based cell projection

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00260 Glycine, serine and threonine metabolism hsa00350 Tyrosine metabolism hsa00360 Phenylalanine metabolism hsa00410 beta-Alanine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-211859: Biological oxidations R-HSA-1430728: Metabolism R-HSA-211945: Phase 1 - Functionalization of compounds

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between AOC3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between AOC3 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
19789345	Melanoma; Lymphoma	Inhibit immunity	We found an unexpected defect in tumor angiogenesis in the absence of VAP-1. VAP-1 also selectively enhanced the recruitment of Gr-1+CD11b+ myeloid cells into the tumors. Generation of mice expressing enzymatically inactive VAP-1 showed that the oxidase activity of VAP-1 was necessary to support neoangiogenesis, myeloid cell recruitment, and tumor growth in vivo.

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of AOC3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of AOC3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.801	0.0333
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.952	0.494
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.677	0.428
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.536	0.418
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.547	0.824
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.531	0.856
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.562	0.261
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.146	0.361
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.077	0.956
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.783	0.633
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.461	0.241
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.448	0.0145

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of AOC3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	0	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	0	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AOC3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AOC3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AOC3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AOC3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of AOC3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between AOC3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	AOC3
Name	amine oxidase, copper containing 3
Aliases	VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ......
Chromosomal Location	17q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting AOC3 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting AOC3.

ID	Name	Drug Type	Targets	#Targets
DB00780	Phenelzine	Small Molecule	ABAT, AOC3, GPT, GPT2, MAOA, MAOB	6
DB01275	Hydralazine	Small Molecule	AOC3, P4HA1	2
DB04334	6-hydroxydopa quinone	Small Molecule	AOC3	1

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