Welcome to TISIDB

The interaction between tumor and immune system plays a crucial role in cancer initiation, progression, and treatment. Cytolytic immune cells (T/NK cells) originally aim to recognize and kill cancer cells, whereas tumor tissue is capable of shaping the surrounding microenvironment to facilitate immune evasion. In particular, tumors can disrupt T/NK cell infiltration, T/NK cell function, and antigen presentation through soluble and cell-surface mediators (e.g. PD-L1) and immunosuppressive cells such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Therefore, elucidation of tumor and immune cell interplay would assist both the prediction of immunotherapy responses and the development of novel immunotherapy targets.

TISIDB is a web portal for tumor and immune system interaction, which integrates multiple heterogeneous data types. They pertain to:

• Literature mining results from PubMed database.

• High throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for detecting resistance and sensitivity of tumor cells to T cell-mediated killing.

• Exome and RNA sequencing data set of patient cohorts with immunotherapy (responders and non-responders).

• Genomics, transcriptomics and clinical data of 30 cancer types from The Cancer Genome Atlas (TCGA).

• Public databases, including UniProt, GO, DrugBank etc.

These data are integrated into ten categories of information for each gene. Click here for more details. We believe TISIDB would become a valuable resource for cancer immunology research and therapy.