AmiGO 2: Term Details for "fatty acid elongase activity" (GO:0009922)

Accession: GO:0009922
Name: fatty acid elongase activity
Ontology: molecular_function
Synonyms: ELOVL, elongation of very long chain fatty acids activity, very-long-chain 3-ketoacyl-CoA synthase, very-long-chain 3-oxoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme
Alternate IDs: None
Definition: Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. Source: PMID:16564093, RHEA:32727, PMID:19763486
Comment: None
History: See term history for GO:0009922 at QuickGO
Chem. react.: has participant malonyl-CoA(5-); has participant very long-chain acyl-CoA(4-); has participant very long-chain 3-oxoacyl-CoA(4-); has participant coenzyme A(4-); has participant hydron; has participant carbon dioxide
Subset: None
Related: Link to all genes and gene products annotated to fatty acid elongase activity (excluding "regulates").; Link to all direct and indirect annotations to fatty acid elongase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for fatty acid elongase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
fatty acid elongase activity	RO:0000057	malonyl-CoA(5-) (CHEBI:57384)
fatty acid elongase activity	RO:0000057	very long-chain acyl-CoA(4-) (CHEBI:90736)
fatty acid elongase activity	RO:0000057	very long-chain 3-oxoacyl-CoA(4-) (CHEBI:90725)
fatty acid elongase activity	RO:0000057	coenzyme A(4-) (CHEBI:57287)
fatty acid elongase activity	is_a	acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)
fatty acid elongase activity	RO:0000057	hydron (CHEBI:15378)
fatty acid elongase activity	RO:0000057	carbon dioxide (CHEBI:16526)

subject	relation	object
fatty acid elongase complex (GO:0009923)	RO:0002215	fatty acid elongase activity

EC: 2.3.1.199
MetaCyc: RXN-7697
Reactome: R-HSA-548830; R-HSA-2046100; R-HSA-2046088; R-HSA-2046090; R-HSA-548800; R-HSA-2046083; R-HSA-548815; R-HSA-2046094; R-HSA-548814; R-HSA-2046095
RHEA: 32727

fatty acid elongase activity